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Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites.
Sköld, Niklas; Nielsen, Birgitte; Olsen, Jacob; Han, Liwei; Olsen, Lars; Madsen, Ulf; Kristensen, Jesper L; Pickering, Darryl S; Johansen, Tommy N.
Afiliación
  • Sköld N; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, Jagtvej 162, DK-2100 Copenhagen, Denmark.
  • Nielsen B; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, Jagtvej 162, DK-2100 Copenhagen, Denmark.
  • Olsen J; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, Jagtvej 162, DK-2100 Copenhagen, Denmark.
  • Han L; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, Jagtvej 162, DK-2100 Copenhagen, Denmark.
  • Olsen L; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, Jagtvej 162, DK-2100 Copenhagen, Denmark.
  • Madsen U; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, Jagtvej 162, DK-2100 Copenhagen, Denmark.
  • Kristensen JL; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, Jagtvej 162, DK-2100 Copenhagen, Denmark.
  • Pickering DS; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, Jagtvej 162, DK-2100 Copenhagen, Denmark.
  • Johansen TN; University of Copenhagen, Faculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, Jagtvej 162, DK-2100 Copenhagen, Denmark. Electronic address: tnj@sund.ku.dk.
Bioorg Med Chem ; 22(19): 5368-77, 2014 Oct 01.
Article en En | MEDLINE | ID: mdl-25172149

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fenilalanina / Diseño de Fármacos / Receptores de Ácido Kaínico Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article País de afiliación: Dinamarca

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fenilalanina / Diseño de Fármacos / Receptores de Ácido Kaínico Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article País de afiliación: Dinamarca