A mononuclear manganese(II) complex demonstrates a strategy to simultaneously image and treat oxidative stress.
J Am Chem Soc
; 136(37): 12836-9, 2014 Sep 17.
Article
en En
| MEDLINE
| ID: mdl-25187295
ABSTRACT
A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM(-1) s(-1), providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Estrés Oxidativo
/
Medios de Contraste
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Complejos de Coordinación
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Peróxido de Hidrógeno
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Manganeso
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Antioxidantes
Límite:
Animals
Idioma:
En
Revista:
J Am Chem Soc
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos