Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells.

Ben-David, Uri; Arad, Gal; Weissbein, Uri; Mandefro, Berhan; Maimon, Adva; Golan-Lev, Tamar; Narwani, Kavita; Clark, Amander T; Andrews, Peter W; Benvenisty, Nissim; Carlos Biancotti, Juan

Ben-David, Uri; Arad, Gal; Weissbein, Uri; Mandefro, Berhan; Maimon, Adva; Golan-Lev, Tamar; Narwani, Kavita; Clark, Amander T; Andrews, Peter W; Benvenisty, Nissim; Carlos Biancotti, Juan.

Afiliación

Ben-David U; 1] Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel [2] Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Arad G; Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel.
Weissbein U; Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel.
Mandefro B; Department of Biomedical Sciences and Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Maimon A; Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel.
Golan-Lev T; Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel.
Narwani K; Department of Biomedical Sciences and Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Clark AT; 1] Department of Molecular, Cell, and Developmental Biology, University of California-Los Angeles, Los Angeles, California 90095, USA [2] Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California-Los Angeles, Los Angeles, California 90095, USA.
Andrews PW; Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.
Benvenisty N; Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, Hebrew University, Jerusalem 91904, Israel.
Carlos Biancotti J; 1] Department of Biomedical Sciences and Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90

Nat Commun ; 5: 4825, 2014 Sep 08.

Article en En | MEDLINE | ID: mdl-25198699

Asunto(s)

Carcinogénesis/genética; Proliferación Celular/genética; Cromosomas Humanos Par 12/genética; Regulación Neoplásica de la Expresión Génica/genética; Neoplasias/genética; Células Madre Pluripotentes/metabolismo; ARN Mensajero/metabolismo; Trisomía/genética; Aneuploidia; Técnicas de Cultivo de Célula; Línea Celular Tumoral; Células Madre de Carcinoma Embrionario/metabolismo; Expresión Génica/genética; Perfilación de la Expresión Génica; Humanos; Técnicas In Vitro; Neoplasias de Células Germinales y Embrionarias/genética; Teratocarcinoma/genética; Teratoma/genética

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trisomía / Cromosomas Humanos Par 12 / ARN Mensajero / Regulación Neoplásica de la Expresión Génica / Células Madre Pluripotentes / Proliferación Celular / Carcinogénesis / Neoplasias Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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