Antibody responses following induction of antigen-specific tolerance with antigen-coupled cells.
Mult Scler
; 21(5): 651-5, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25200502
ABSTRACT
We have recently demonstrated the safety and tolerability of a novel therapeutic regimen employing autologous blood cells chemically coupled with seven myelin peptides to induce antigen-specific tolerance in MS (ETIMS study). The aim of the current study was an extended safety analysis to assess the effect of the ETIMS approach on antibodies to common autoantigens, the myelin peptides used and common recall antigens. None of the patients showed induction of autoantibody responses. One patient had a measurable myelin peptide-specific response at baseline, which was reduced after treatment. Total immunoglobulins and recall antibody responses showed no significant change.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Autoantígenos
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Células Sanguíneas
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Vacunas
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Tolerancia Inmunológica
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Formación de Anticuerpos
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Esclerosis Múltiple
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Mult Scler
Asunto de la revista:
NEUROLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Austria