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The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion.
Dölker, Nicole; Górna, Maria W; Sutto, Ludovico; Torralba, Antonio S; Superti-Furga, Giulio; Gervasio, Francesco L.
Afiliación
  • Dölker N; Structural Biology and Biocomputing Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
  • Górna MW; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Sutto L; Institute of Structural and Molecular Biology, University College London, London, United Kingdom.
  • Torralba AS; Structural Biology and Biocomputing Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
  • Superti-Furga G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Gervasio FL; Institute of Structural and Molecular Biology, University College London, London, United Kingdom; Chemistry Department, University College London (UCL), London, United Kingdom.
PLoS Comput Biol ; 10(10): e1003863, 2014 Oct.
Article en En | MEDLINE | ID: mdl-25299346

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-abl / Ciclinas / Dominios Homologos src Límite: Humans Idioma: En Revista: PLoS Comput Biol Asunto de la revista: BIOLOGIA / INFORMATICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-abl / Ciclinas / Dominios Homologos src Límite: Humans Idioma: En Revista: PLoS Comput Biol Asunto de la revista: BIOLOGIA / INFORMATICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: España