Regioselective C-H imidation of five-membered heterocyclic compounds through a metal catalytic or organocatalytic approach.

ABSTRACT

An efficient method for the synthesis of 2-amino and ß-amino five-membered heterocyclic derivatives that are closely related to a variety of biologically active natural products is described. Regioselectivity was achieved through a metal catalytic or organocatalytic approach. Preliminary studies on the reaction mechanism suggest a radical imidation pathway; however, further studies are needed to verify the mechanism.