Use of antidepressants and association with elective termination of pregnancy: population based case-control study.
BJOG
; 122(12): 1618-24, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-25395328
ABSTRACT
OBJECTIVE:
To assess whether the use of selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, mirtazapine, venlafaxine or other antidepressants is associated with late elective termination of pregnancy.DESIGN:
Case-control study using data from national registers.SETTING:
Denmark, Finland, and Norway during the period 1996-2007. POPULATION A total of 14,902 women were included as cases and 148,929 women were included as controls.METHODS:
Cases were women with elective termination of pregnancy at 12-23 weeks of gestation. Controls continued their pregnancy and were matched with cases on key factors. MAIN OUTCOMEMEASURES:
Association between antidepressant use during pregnancy and elective termination of pregnancy at 12-23 weeks of gestation for fetal anomalies, or for maternal ill health or socio-economic disadvantage.RESULTS:
At least one prescription of antidepressants was filled by 3.7% of the cases and 2.2% of the controls. Use of any type of antidepressant was associated with elective termination of pregnancy for maternal ill health or socio-economic disadvantage (odds ratio, OR 2.3; 95% confidence interval, 95% CI 2.0-2.5). Elective termination of pregnancy for fetal anomalies was associated with the use of mirtazapine (OR 2.2, 95% CI 1.1-4.5). There was no association between the use of any of the other antidepressants and elective termination of pregnancy for fetal anomalies.CONCLUSION:
The use of any type of antidepressants was associated with elective termination of pregnancy at 12-23 weeks for maternal ill health or socio-economic disadvantage, but not with terminations for fetal anomalies. Further studies need to confirm the findings concerning mirtazapine and termination of pregnancy for fetal anomalies.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ultrasonografía Prenatal
/
Aborto Inducido
/
Inhibidores Selectivos de la Recaptación de Serotonina
/
Depresión
/
Mianserina
/
Antidepresivos
/
Antidepresivos Tricíclicos
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
BJOG
Asunto de la revista:
GINECOLOGIA
/
OBSTETRICIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Suecia