Platelet function monitoring in elderly patients on prasugrel after stenting for an acute coronary syndrome: design of the randomized antarctic study.
Am Heart J
; 168(5): 674-81, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-25440795
ABSTRACT
BACKGROUND:
Elderly patients are at high risk for both ischemic and bleeding events. Platelet monitoring offers the opportunity to individualized antiplatelet therapy to optimize the therapeutic risk/benefit ratio. STUDYDESIGN:
The ANTARCTIC study is designed to demonstrate the superiority of a strategy of platelet function monitoring with dose and drug adjustment in patients initially on prasugrel 5 mg as compared with a more conventional strategy using prasugrel 5 mg without monitoring and without adjustment (Conventional Treatment Arm) to reduce the primary end point evaluated 1 year after stent percutaneous coronary intervention in elderly patients presenting with an acute coronary syndrome (ACS). ANTARCTIC is a multicenter, prospective, open-label study with 2 parallel arms. A total of 852 elderly patients (≥ 75 years) undergoing stent percutaneous coronary intervention for ACS are to be enrolled. The primary end point is the time to first occurrence of cardiovascular death, myocardial infarction, stroke, definite stent thrombosis, urgent revascularization, and bleeding complications (Bleeding Academic Research Consortium definition 2, 3, or 5). Platelet function analyses will be performed 14 days after randomization and repeated 14 days later in patients who require a change in treatment.CONCLUSION:
ANTARCTIC is a nationwide, prospective, open-label study testing a strategy of platelet function monitoring with dose and drug adjustment to reduce ischemic and bleeding complications in elderly ACS patients undergoing coronary stenting.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piperazinas
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Tiofenos
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Stents
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Monitoreo de Drogas
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Isquemia Miocárdica
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Síndrome Coronario Agudo
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Antagonistas del Receptor Purinérgico P2Y
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Intervención Coronaria Percutánea
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Hemorragia
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Am Heart J
Año:
2014
Tipo del documento:
Article
País de afiliación:
Francia