Natural history of chronic hepatitis B virus infection.
Med Microbiol Immunol
; 204(1): 5-10, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25540037
ABSTRACT
Hepatitis B virus infection represents a major global health problem. Currently, there are more than 240 million chronically infected people worldwide. The development of chronic hepatitis B virus-mediated liver disease may lead to liver fibrosis, cirrhosis and eventually hepatocellular carcinoma. Recently, the discovery of the viral entry receptor sodium taurocholate cotransporting polypeptide has facilitated new approaches for a better understanding of viral physiopathology. Hopefully, these novel insights may give rise to the development of more effective antiviral therapy concepts during the next years. In this review, we will discuss the natural history of hepatitis B virus infection including the viral biology, the clinical course of infection and the role of the immune response.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Virus de la Hepatitis B
/
Carcinoma Hepatocelular
/
Hepatitis B Crónica
/
Cirrosis Hepática
/
Neoplasias Hepáticas
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Med Microbiol Immunol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania