Poly(L-lactic acid)-modified silica stationary phase for reversed-phase and hydrophilic interaction liquid chromatography.
J Sep Sci
; 38(5): 720-3, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25546473
ABSTRACT
Poly(L-lactic acid) is a linear aliphatic thermoplastic polyester that can be produced from renewable resources. A poly(L-lactic acid)-modified silica stationary phase was newly prepared by amide bond reaction between amino groups on aminopropyl silica and carboxylic acid groups at the end of the poly(L-lactic acid) chain. The poly(L-lactic acid)-silica column was characterized in reversed-phase liquid chromatography and hydrophilic interaction liquid chromatography with the use of different mobile phase compositions. The poly(L-lactic acid)-silica column was found to work in both modes, and the retention of test compounds depending on acetonitrile content exhibited "U-shaped" curves, which was an indicator of reversed-phase liquid chromatography/hydrophilic interaction liquid chromatography mixed-mode retention behavior. In addition, carbonyl groups included into the poly(L-lactic acid) backbone work as an electron-accepting group toward a polycyclic aromatic hydrocarbon and provide π-π interactions.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Polímeros
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Cromatografía Líquida de Alta Presión
/
Dióxido de Silicio
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Ácido Láctico
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Cromatografía de Fase Inversa
Idioma:
En
Revista:
J Sep Sci
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón