Morusin inhibits glioblastoma stem cell growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis induction.

Guo, Huijie; Liu, Chuanlan; Yang, Liuqi; Dong, Lihua; Wang, Li; Wang, Qiaoping; Li, Haiyan; Zhang, Jie; Lin, Ping; Wang, Xiujie

Guo, Huijie; Liu, Chuanlan; Yang, Liuqi; Dong, Lihua; Wang, Li; Wang, Qiaoping; Li, Haiyan; Zhang, Jie; Lin, Ping; Wang, Xiujie.

Afiliación

Guo H; Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, West China Clinical Medical School, Sichuan University, Chengdu, China.
Liu C; Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, China.
Yang L; Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, West China Clinical Medical School, Sichuan University, Chengdu, China.
Dong L; Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, West China Clinical Medical School, Sichuan University, Chengdu, China.
Wang L; Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, West China Clinical Medical School, Sichuan University, Chengdu, China.
Wang Q; Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, West China Clinical Medical School, Sichuan University, Chengdu, China.
Li H; Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, West China Clinical Medical School, Sichuan University, Chengdu, China.
Zhang J; Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, West China Clinical Medical School, Sichuan University, Chengdu, China.
Lin P; Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, West China Clinical Medical School, Sichuan University, Chengdu, China.
Wang X; Laboratory of Experimental Oncology, State Key Laboratory of Biotherapy, West China Hospital, West China Clinical Medical School, Sichuan University, Chengdu, China.

Mol Carcinog ; 55(1): 77-89, 2016 Jan.

Article en En | MEDLINE | ID: mdl-25557841

Asunto(s)

Apoptosis/efectos de los fármacos; Autorrenovación de las Células/efectos de los fármacos; Transdiferenciación Celular/efectos de los fármacos; Flavonoides/farmacología; Glioblastoma/metabolismo; Glioblastoma/patología; Células Madre Neoplásicas/efectos de los fármacos; Células Madre Neoplásicas/metabolismo; Animales; Apoptosis/genética; Biomarcadores; Línea Celular Tumoral; Fragmentación del ADN/efectos de los fármacos; Modelos Animales de Enfermedad; Expresión Génica; Glioblastoma/genética; Humanos; Ratones; Esferoides Celulares; Carga Tumoral; Células Tumorales Cultivadas

Palabras clave

Adipocyte transdifferentiation; Apoptosis; Cancer stem cells; Glioblastoma multiforme; Growth inhibition; Morusin

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Flavonoides / Apoptosis / Glioblastoma / Transdiferenciación Celular / Autorrenovación de las Células Límite: Animals / Humans Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: China

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