Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patients.
AIDS
; 28(17): 2627-2631, 2014 Nov 13.
Article
en En
| MEDLINE
| ID: mdl-25574964
ABSTRACT
This retrospective study was designed to assess statin effects on T-cell activation from HIV-infected individuals. Peripheral blood mononuclear cells from antiretroviral therapy suppressed HIV-infected individuals receiving atorvastatin or pravastatin were evaluated for T-cell activation, exhaustion and function. Atorvastatin was associated with a significant reduction in CD8 T-cell activation (HLA-DR, CD38/HLA-DR) and exhaustion (TIM-3, TIM-3/PD-1) whereas pravastatin had no effect. In contrast, pravastatin increased antigen specific interferon γ production. These results suggest a differential effect of statins on immune activation and function.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pirroles
/
Activación de Linfocitos
/
Linfocitos T
/
Infecciones por VIH
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VIH-1
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Pravastatina
/
Ácidos Heptanoicos
/
Anticolesterolemiantes
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
AIDS
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2014
Tipo del documento:
Article