Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation.

Goodwin, Nicole C; Cianchetta, Giovanni; Burgoon, Hugh A; Healy, Jason; Mabon, Ross; Strobel, Eric D; Allen, Jason; Wang, Shuli; Hamman, Brian D; Rawlins, David B

Goodwin, Nicole C; Cianchetta, Giovanni; Burgoon, Hugh A; Healy, Jason; Mabon, Ross; Strobel, Eric D; Allen, Jason; Wang, Shuli; Hamman, Brian D; Rawlins, David B.

Afiliación

Goodwin NC; Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States.
Cianchetta G; Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States.
Burgoon HA; Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States.
Healy J; Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States.
Mabon R; Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States.
Strobel ED; Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States.
Allen J; Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States.
Wang S; Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States.
Hamman BD; Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States.
Rawlins DB; Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States.

ACS Med Chem Lett ; 6(1): 53-7, 2015 Jan 08.

Article en En | MEDLINE | ID: mdl-25589930

Palabras clave

DFG-out; LIM kinase 2; allosteric; noncompetitive; selective; type III kinase inhibitor

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos