Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter.
Molecules
; 20(1): 1712-30, 2015 Jan 20.
Article
en En
| MEDLINE
| ID: mdl-25608857
ABSTRACT
Since the norepinephrine transporter (NET) is involved in a variety of diseases, the investigation of underlying dysregulation-mechanisms of the norepinephrine (NE) system is of major interest. Based on the previously described highly potent and selective NET ligand 1-(3-(methylamino)-1-phenylpropyl)-3-phenyl-1,3-dihydro-2H-benzimidaz- ol-2-one (Me@APPI), this paper aims at the development of several fluorinated methylamine-based analogs of this compound. The newly synthesized compounds were computationally evaluated for their interactions with the monoamine transporters and represent reference compounds for PET-based investigation of the NET.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Simulación por Computador
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Radiofármacos
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Tomografía de Emisión de Positrones
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Proteínas de Transporte de Noradrenalina a través de la Membrana Plasmática
Límite:
Humans
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Austria