Enantioselective synthesis of dictyoceratin-A (smenospondiol) and -C, hypoxia-selective growth inhibitors from marine sponge.
Bioorg Med Chem
; 23(5): 966-75, 2015 Mar 01.
Article
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| MEDLINE
| ID: mdl-25659617
ABSTRACT
Total syntheses of (+)-dictyoceratin-C (1) and (+)-dictyoceratin-A (smenospondiol) (2), hypoxia-selective growth inhibitors isolated from marine sponge, were executed. The absolute stereochemistry of the each compound was determined through the enantioselective total syntheses of them. It revealed that the unnatural enantiomers of them also exhibited the hypoxia-selective growth inhibitory activity against human prostate cancer DU-145 cells.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Poríferos
/
Sesquiterpenos
/
Proliferación Celular
/
Inhibidores de Crecimiento
/
Hidroxibenzoatos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón