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siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytes.
Matsuda, Shigeo; Keiser, Kristofer; Nair, Jayaprakash K; Charisse, Klaus; Manoharan, Rajar M; Kretschmer, Philip; Peng, Chang G; V Kel'in, Alexander; Kandasamy, Pachamuthu; Willoughby, Jennifer L S; Liebow, Abigail; Querbes, William; Yucius, Kristina; Nguyen, Tuyen; Milstein, Stuart; Maier, Martin A; Rajeev, Kallanthottathil G; Manoharan, Muthiah.
Afiliación
  • Matsuda S; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Keiser K; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Nair JK; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Charisse K; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Manoharan RM; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Kretschmer P; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Peng CG; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • V Kel'in A; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Kandasamy P; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Willoughby JL; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Liebow A; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Querbes W; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Yucius K; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Nguyen T; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Milstein S; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Maier MA; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Rajeev KG; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
  • Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
ACS Chem Biol ; 10(5): 1181-7, 2015 May 15.
Article en En | MEDLINE | ID: mdl-25730476
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Acetilgalactosamina / Silenciador del Gen / Hepatocitos / ARN Interferente Pequeño / Nucleósidos Límite: Animals Idioma: En Revista: ACS Chem Biol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Acetilgalactosamina / Silenciador del Gen / Hepatocitos / ARN Interferente Pequeño / Nucleósidos Límite: Animals Idioma: En Revista: ACS Chem Biol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos