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Population structure of Neisseria gonorrhoeae based on whole genome data and its relationship with antibiotic resistance.
Ezewudo, Matthew N; Joseph, Sandeep J; Castillo-Ramirez, Santiago; Dean, Deborah; Del Rio, Carlos; Didelot, Xavier; Dillon, Jo-Anne; Selden, Richard F; Shafer, William M; Turingan, Rosemary S; Unemo, Magnus; Read, Timothy D.
Afiliación
  • Ezewudo MN; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine , Atlanta, GA , USA.
  • Joseph SJ; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine , Atlanta, GA , USA.
  • Castillo-Ramirez S; Programa de Genómica Evolutiva, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México , Cuernavaca, Morelos , México.
  • Dean D; Children's Hospital Oakland Research Institute , Oakland, CA , USA ; University of San Francisco at California, Division of Infectious Diseases , San Francisco, CA , USA.
  • Del Rio C; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine , Atlanta, GA , USA ; Hubert Department of Global Health, Rollins School of Public Health of Emory University , Atlanta, GA , USA.
  • Didelot X; Department of Infectious Disease Epidemiology, Imperial College London , London , UK.
  • Dillon JA; Department of Microbiology and Immunology, College of Medicine, Vaccine and Infectious Disease Organization International Vaccine Centre, University of Saskatchewan , Saskatoon, Saskatchewan , Canada.
  • Selden RF; NetBio , Waltham, MA , USA.
  • Shafer WM; Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, GA , USA ; Laboratories of Bacterial Pathogenesis, Veterans Affairs Medical Center , Decatur, GA , USA.
  • Turingan RS; NetBio , Waltham, MA , USA.
  • Unemo M; WHO Collaborating Centre for Gonorrhoea and other STIs, Örebro University Hospital , Örebro , Sweden.
  • Read TD; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine , Atlanta, GA , USA.
PeerJ ; 3: e806, 2015.
Article en En | MEDLINE | ID: mdl-25780762
ABSTRACT
Neisseria gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection (STI) of major importance. As a result of antibiotic resistance, there are now limited options for treating patients. We collected draft genome sequence data and associated metadata data on 76 N. gonorrhoeae strains from around the globe and searched for known determinants of antibiotics resistance within the strains. The population structure and evolutionary forces within the pathogen population were analyzed. Our results indicated a cosmopolitan gonoccocal population mainly made up of five subgroups. The estimated ratio of recombination to mutation (r/m = 2.2) from our data set indicates an appreciable level of recombination occurring in the population. Strains with resistance phenotypes to more recent antibiotics (azithromycin and cefixime) were mostly found in two of the five population subgroups.
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: PeerJ Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: PeerJ Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos