[The effects of DNA methylation on the homeostasis in vascular diseases].
Yi Chuan
; 37(3): 221-232, 2015 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-25786996
ABSTRACT
Homeostasis is fundamental to maintain normal physiological functions in our body. Internal and external physical, chemical and biologial changes can cause dysregulation of vascular homeostasis, which is closely associated with the homeostasis of oxygen supply, blood transportation and lipid metabolism. Subsequent epigenetic modifications are able to lead to abnormal structures and function of vessels. DNA methylation has been shown to play a vital role in the development of vascular diseases. In addition, 5-hydroxymethylcytosine (5hmC) and N(6)-methyladenine (m(6)A), as new epigenetic modifications, provide additional clues for vascular diseases. In this review, we summarize the effects of DNA methylation on the homeostasis dysregulation in the vascular diseases.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Vasculares
/
Metilación de ADN
/
Homeostasis
Límite:
Humans
Idioma:
Zh
Revista:
Yi Chuan
Asunto de la revista:
GENETICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
China