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Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Miller, Matthew S; Rialdi, Alexander; Ho, Jessica Sook Yuin; Tilove, Micah; Martinez-Gil, Luis; Moshkina, Natasha P; Peralta, Zuleyma; Noel, Justine; Melegari, Camilla; Maestre, Ana M; Mitsopoulos, Panagiotis; Madrenas, Joaquín; Heinz, Sven; Benner, Chris; Young, John A T; Feagins, Alicia R; Basler, Christopher F; Fernandez-Sesma, Ana; Becherel, Olivier J; Lavin, Martin F; van Bakel, Harm; Marazzi, Ivan.
Afiliación
  • Miller MS; 1] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Biochemistry and Biomedical Sciences, Institute for Infectious Diseases Research, McMaster Immunology Research Centre, McMaster University, Hamilton, Canada.
  • Rialdi A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Ho JS; Laboratory of Methyltransferases in Development and Disease, Institute of Molecular and Cell Biology, Singapore.
  • Tilove M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Martinez-Gil L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Moshkina NP; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Peralta Z; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Noel J; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Melegari C; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Maestre AM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Mitsopoulos P; Microbiome and Disease Tolerance Centre, Department of Microbiology and Immunology, McGill University, Montreal, Canada.
  • Madrenas J; Microbiome and Disease Tolerance Centre, Department of Microbiology and Immunology, McGill University, Montreal, Canada.
  • Heinz S; The Salk Institute for Biological Studies, La Jolla, California, USA.
  • Benner C; The Salk Institute for Biological Studies, La Jolla, California, USA.
  • Young JA; F. Hoffmann-La Roche, Basel, Switzerland.
  • Feagins AR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Fernandez-Sesma A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Becherel OJ; The University of Queensland, UQ Centre for Clinical Research, Herston, Australia.
  • Lavin MF; The University of Queensland, UQ Centre for Clinical Research, Herston, Australia.
  • van Bakel H; 1] Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Marazzi I; 1] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nat Immunol ; 16(5): 485-94, 2015 May.
Article en En | MEDLINE | ID: mdl-25822250
ABSTRACT
The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived from patients with AOA2 had higher expression of antiviral mediators in response to infection than did wild-type cells. Mechanistically, we propose a model whereby SETX attenuates the activity of RNA polymerase II (RNAPII) at genes stimulated after a virus is sensed and thus controls the magnitude of the host response to pathogens and the biogenesis of various RNA viruses (e.g., influenza A virus and West Nile virus). Our data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Orthomyxoviridae / Fiebre del Nilo Occidental / Virus del Nilo Occidental / ARN Polimerasa II / Degeneraciones Espinocerebelosas / ARN Helicasas / Gripe Humana / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Orthomyxoviridae / Fiebre del Nilo Occidental / Virus del Nilo Occidental / ARN Polimerasa II / Degeneraciones Espinocerebelosas / ARN Helicasas / Gripe Humana / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá