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Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme.
Evelyn, Chris R; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi.
Afiliación
  • Evelyn CR; From the Division of Experimental Hematology and Cancer Biology.
  • Biesiada J; Division of Biomedical Informatics.
  • Duan X; From the Division of Experimental Hematology and Cancer Biology.
  • Tang H; Division of Immunobiology, and the Drug Discovery Center and.
  • Shang X; From the Division of Experimental Hematology and Cancer Biology.
  • Papoian R; the Drug Discovery Center and Departments of Neurology and.
  • Seibel WL; the Drug Discovery Center and Division of Oncology, Children's Hospital Research Foundation, Cincinnati, Ohio 45229 and.
  • Nelson S; the Drug Discovery Center and.
  • Meller J; Division of Biomedical Informatics, Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267.
  • Zheng Y; From the Division of Experimental Hematology and Cancer Biology, Yi.Zheng@cchmc.org.
J Biol Chem ; 290(20): 12879-98, 2015 May 15.
Article en En | MEDLINE | ID: mdl-25825487
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Activadoras de ras GTPasa / Factores de Intercambio de Guanina Nucleótido ras / Inhibidores Enzimáticos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Activadoras de ras GTPasa / Factores de Intercambio de Guanina Nucleótido ras / Inhibidores Enzimáticos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article