Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population.
Genet Mol Res
; 14(1): 1899-902, 2015 Mar 13.
Article
en En
| MEDLINE
| ID: mdl-25867335
ABSTRACT
In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population. We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls. We found that the CC genotype was more frequent in the osteosarcoma group compared to the control group (P = 0.011). We also found that the C allele was more common in osteosarcoma patients than that in control subjects (P = 0.004). Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Osteosarcoma
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
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Pueblo Asiatico
/
RecQ Helicasas
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Genet Mol Res
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
China