Fighting Sleep at Night: Brain Correlates and Vulnerability to Sleep Loss.
Ann Neurol
; 78(2): 235-47, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-25940842
ABSTRACT
OBJECTIVE:
Even though wakefulness at night leads to profound performance deterioration and is regularly experienced by shift workers, its cerebral correlates remain virtually unexplored.METHODS:
We assessed brain activity in young healthy adults during a vigilant attention task under high and low sleep pressure during night-time, coinciding with strongest circadian sleep drive. We examined sleep-loss-related attentional vulnerability by considering a PERIOD3 polymorphism presumably impacting on sleep homeostasis.RESULTS:
Our results link higher sleep-loss-related attentional vulnerability to cortical and subcortical deactivation patterns during slow reaction times (i.e., suboptimal vigilant attention). Concomitantly, thalamic regions were progressively less recruited with time-on-task and functionally less connected to task-related and arousal-promoting brain regions in those volunteers showing higher attentional instability in their behavior. The data further suggest that the latter is linked to shifts into a task-inactive default-mode network in between task-relevant stimulus occurrence.INTERPRETATION:
We provide a multifaceted view on cerebral correlates of sleep loss at night and propose that genetic predisposition entails differential cerebral coping mechanisms, potentially compromising adequate performance during night work.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Nivel de Alerta
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Tiempo de Reacción
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Atención
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Privación de Sueño
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Encéfalo
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Ritmo Circadiano
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Proteínas Circadianas Period
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Ann Neurol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Suiza