Soluble Glycoprotein Is Not Required for Ebola Virus Virulence in Guinea Pigs.
J Infect Dis
; 212 Suppl 2: S242-6, 2015 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-25957965
ABSTRACT
Ebola virus (EBOV) uses transcriptional editing to express several glycoproteins (GPs), including secreted soluble GP (sGP) and structural GP1,2, from a single gene. Recombinant viruses predominantly expressing GP1,2 are known to rapidly mutate and acquire an editing site predominantly expressing sGP in vivo, suggesting an important role of this protein during infection. Therefore, we generated a recombinant virus that is no longer able to express sGP and assessed its virulence in the EBOV guinea pig model. Surprisingly, although this virus remained genetically stable, it did not show any significant attenuation in vivo, showing that sGP is not required for virulence in this model.
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MEDLINE
Asunto principal:
Proteínas Virales
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Virulencia
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Glicoproteínas
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Fiebre Hemorrágica Ebola
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Ebolavirus
Límite:
Animals
Idioma:
En
Revista:
J Infect Dis
Año:
2015
Tipo del documento:
Article