Costs and cost-effectiveness of a large-scale mass testing and treatment intervention for malaria in Southern Province, Zambia.
Malar J
; 14: 211, 2015 May 20.
Article
en En
| MEDLINE
| ID: mdl-25985992
ABSTRACT
BACKGROUND:
A cluster, randomized, control trial of three dry-season rounds of a mass testing and treatment intervention (MTAT) using rapid diagnostic tests (RDTs) and artemether-lumefantrine (AL) was conducted in four districts in Southern Province, Zambia.METHODS:
Data were collected on the costs and logistics of the intervention and paired with effectiveness estimated from a community randomized control trial for the purpose of conducting a provider perspective cost-effectiveness analysis of MTAT vs no MTAT (Standard of Care).RESULTS:
Dry-season MTAT in this setting did not reduce malaria transmission sufficiently to permit transition to a case-investigation strategy to then pursue malaria elimination, however, the intervention did substantially reduce malaria illness and was a highly cost-effective intervention for malaria burden reduction in this moderate transmission area. The cost per RDT administered was estimated to be USD4.39 (range USD1.62-13.96) while the cost per AL treatment administered was estimated to be USD34.74 (range USD3.87-3,835). The net cost per disability adjusted life year averted (incremental cost-effectiveness ratio) was estimated to be USD804.CONCLUSIONS:
The intervention appears to be highly cost-effective relative to World Health Organization thresholds for malaria burden reduction in Zambia as compared to no MTAT. However, it was estimated that population-wide mass drug administration is likely to be more cost-effective for burden reduction and for transmission reduction compared to MTAT.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tamizaje Masivo
/
Artemisininas
/
Pruebas Diagnósticas de Rutina
/
Etanolaminas
/
Fluorenos
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Malaria
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Antimaláricos
Tipo de estudio:
Clinical_trials
/
Health_economic_evaluation
/
Screening_studies
País/Región como asunto:
Africa
Idioma:
En
Revista:
Malar J
Asunto de la revista:
MEDICINA TROPICAL
Año:
2015
Tipo del documento:
Article
País de afiliación:
Zambia