PPAR-&#945; agonist regulates amyloid-ß generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe gene.

Zhang, Hua; Gao, Ying; Qiao, Pei-feng; Zhao, Feng-li; Yan, Yong

PPAR-α agonist regulates amyloid-ß generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe gene.

Zhang, Hua; Gao, Ying; Qiao, Pei-feng; Zhao, Feng-li; Yan, Yong.

Afiliación

Zhang H; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Chongqing, 400016, China. zhanghua0303@hotmail.com.
Gao Y; Special Wards, The Affiliated Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Qiao PF; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Chongqing, 400016, China.
Zhao FL; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Chongqing, 400016, China.
Yan Y; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Chongqing, 400016, China. yongyanpro@hotmail.com.

Mol Cell Biochem ; 408(1-2): 37-46, 2015 Oct.

Article en En | MEDLINE | ID: mdl-26092426

Asunto(s)

Secretasas de la Proteína Precursora del Amiloide/metabolismo; Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Ácido Aspártico Endopeptidasas/metabolismo; Butiratos/farmacología; Neuroblastoma/metabolismo; PPAR alfa/agonistas; Fragmentos de Péptidos/metabolismo; Compuestos de Fenilurea/farmacología; Precursor de Proteína beta-Amiloide/metabolismo; Línea Celular Tumoral; Humanos; Presenilina-1/metabolismo; Transducción de Señal/efectos de los fármacos; Transfección

Palabras clave

Alzheimer's disease; Amyloid-ß; Beta-site amyloid precursor protein cleaving enzyme 1; GW7647; Peroxisome proliferator-activated receptor alpha; Phosphoinositide 3-kinase

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Compuestos de Fenilurea / Butiratos / Péptidos beta-Amiloides / Ácido Aspártico Endopeptidasas / Precursor de Proteína beta-Amiloide / PPAR alfa / Secretasas de la Proteína Precursora del Amiloide / Neuroblastoma Límite: Humans Idioma: En Revista: Mol Cell Biochem Año: 2015 Tipo del documento: Article País de afiliación: China

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google