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Potent benzoazepinone γ-secretase modulators with improved bioavailability.
Methot, Joey L; Fischer, Christian; Li, Chaomin; Rivkin, Alexey; Ahearn, Sean P; Brown, William Colby; Kattar, Sam; Kelley, Elizabeth; Mampreian, Dawn M; Schell, Adam; Rosenau, Andrew; Zhou, Hua; Ball, Richard; Deshmukh, Sujal V; Jeliazkova-Mecheva, Valentina V; Diaz, Damaris; Moy, Lily Y; Kenific, Candia M; Moxham, Chris; Shah, Sanjiv; Nuthall, Hugh; Szewczak, Alexander A; Hill, Armetta; Hughes, Bethany; Smotrov, Nadya; Munoz, Benito; Miller, Thomas A; Shearman, Mark S.
Afiliación
  • Methot JL; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: joey_methot@merck.com.
  • Fischer C; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Li C; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Rivkin A; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Ahearn SP; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Brown WC; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Kattar S; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Kelley E; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Mampreian DM; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Schell A; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Rosenau A; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Zhou H; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Ball R; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Deshmukh SV; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Jeliazkova-Mecheva VV; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Diaz D; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Moy LY; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Kenific CM; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Moxham C; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Shah S; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Nuthall H; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Szewczak AA; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Hill A; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Hughes B; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Smotrov N; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Munoz B; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Miller TA; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Shearman MS; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.
Bioorg Med Chem Lett ; 25(17): 3495-500, 2015 Sep 01.
Article en En | MEDLINE | ID: mdl-26142947
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article