Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice.

Bhattacharya, Parna; Dey, Ranadhir; Dagur, Pradeep K; Kruhlak, Michael; Ismail, Nevien; Debrabant, Alain; Joshi, Amritanshu B; Akue, Adovi; Kukuruga, Mark; Takeda, Kazuyo; Selvapandiyan, Angamuthu; McCoy, John Philip; Nakhasi, Hira L

Bhattacharya, Parna; Dey, Ranadhir; Dagur, Pradeep K; Kruhlak, Michael; Ismail, Nevien; Debrabant, Alain; Joshi, Amritanshu B; Akue, Adovi; Kukuruga, Mark; Takeda, Kazuyo; Selvapandiyan, Angamuthu; McCoy, John Philip; Nakhasi, Hira L.

Afiliación

Bhattacharya P; Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Dey R; Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Dagur PK; Flow Cytometry Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Kruhlak M; Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Ismail N; Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Debrabant A; Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Joshi AB; Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Akue A; Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Kukuruga M; Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Takeda K; Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Selvapandiyan A; Institute of Molecular Medicine, New Delhi, India.
McCoy JP; Flow Cytometry Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Nakhasi HL; Division of Emerging and Transfusion Transmitted Disease, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA Hira.Nakhasi@fda.hhs.gov.

Infect Immun ; 83(10): 3800-15, 2015 Oct.

Article en En | MEDLINE | ID: mdl-26169275

Asunto(s)

Inmunidad Innata; Leishmania donovani/genética; Leishmania donovani/inmunología; Leishmaniasis Visceral/inmunología; Macrófagos/inmunología; Células TH1/inmunología; Inmunidad Adaptativa; Animales; Quimiocina CCL2/genética; Quimiocina CCL2/inmunología; Quimiocina CCL3/genética; Quimiocina CCL3/inmunología; Femenino; Humanos; Interferón gamma/genética; Interferón gamma/inmunología; Interleucina-12/genética; Interleucina-12/inmunología; Interleucina-6/genética; Interleucina-6/inmunología; Leishmaniasis Visceral/genética; Leishmaniasis Visceral/parasitología; Ratones; Ratones Endogámicos BALB C

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Leishmania donovani / Células TH1 / Inmunidad Innata / Leishmaniasis Visceral / Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Infect Immun Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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