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Arsenic exposure and hepatitis E virus infection during pregnancy.
Heaney, Christopher D; Kmush, Brittany; Navas-Acien, Ana; Francesconi, Kevin; Gössler, Walter; Schulze, Kerry; Fairweather, DeLisa; Mehra, Sucheta; Nelson, Kenrad E; Klein, Sabra L; Li, Wei; Ali, Hasmot; Shaikh, Saijuddin; Merrill, Rebecca D; Wu, Lee; West, Keith P; Christian, Parul; Labrique, Alain B.
Afiliación
  • Heaney CD; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: cheaney1@jhu.edu.
  • Kmush B; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Navas-Acien A; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Francesconi K; Institute of Chemistry-Analytical Chemistry, Graz University, Austria.
  • Gössler W; Institute of Chemistry-Analytical Chemistry, Graz University, Austria.
  • Schulze K; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
  • Fairweather D; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Mehra S; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
  • Nelson KE; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Klein SL; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Li W; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA.
  • Ali H; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
  • Shaikh S; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
  • Merrill RD; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
  • Wu L; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
  • West KP; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
  • Christian P; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
  • Labrique AB; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; The JiVitA Maternal and Child Health and Nutrition Research Project, Gaibandha, Bangladesh.
Environ Res ; 142: 273-80, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26186135
BACKGROUND: Arsenic has immunomodulatory properties and may have the potential to alter susceptibility to infection in humans. OBJECTIVES: We aimed to assess the relation of arsenic exposure during pregnancy with immune function and hepatitis E virus (HEV) infection, defined as seroconversion during pregnancy and postpartum. METHODS: We assessed IgG seroconversion to HEV between 1st and 3rd trimester (TM) and 3 months postpartum (PP) among 1100 pregnancies in a multiple micronutrient supplementation trial in rural Bangladesh. Forty women seroconverted to HEV and were matched with 40 non-seroconverting women (controls) by age, parity and intervention. We assessed urinary inorganic arsenic plus methylated species (∑As) (µg/L) at 1st and 3rd TM and plasma cytokines (pg/mL) at 1st and 3rd TM and 3 months PP. RESULTS: HEV seroconverters' urinary ∑As was elevated throughout pregnancy. Non-seroconverters' urinary ∑As was similar to HEV seroconverters at 1st TM but declined at 3rd TM. The adjusted odds ratio (95% confidence interval) of HEV seroconversion was 2.17 (1.07, 4.39) per interquartile range (IQR) increase in average-pregnancy urinary ∑As. Increased urinary ∑As was associated with increased concentrations of IL-2 during the 1st and 3rd TM and 3 months PP among HEV seroconverters but not non-seroconverters. CONCLUSIONS: The relation of urinary arsenic during pregnancy with incident HEV seroconversion and with IL-2 levels among HEV-seroconverting pregnant women suggests arsenic exposure during pregnancy may enhance susceptibility to HEV infection.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arsénico / Hepatitis E / Contaminantes Ambientales Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Environ Res Año: 2015 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arsénico / Hepatitis E / Contaminantes Ambientales Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Environ Res Año: 2015 Tipo del documento: Article