Sodium salts of anionic chiral cobalt(III) complexes as catalysts of the enantioselective Povarov reaction.
Angew Chem Int Ed Engl
; 54(38): 11209-13, 2015 Sep 14.
Article
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| ID: mdl-26230676
ABSTRACT
The sodium salts of anionic chiral cobalt(III) complexes (CCC(-) Na(+) ) have been found to be efficient catalysts of the asymmetric Povarov reaction of easily accessible dienophiles, such as 2,3-dihydrofuran, ethyl vinyl ether, and an N-protected 2,3-dihydropyrrole, with 2-azadienes. Ring-fused tetrahydroquinolines with up to three contiguous stereogenic centers were thus obtained in high yields, excellent diastereoselectivities (endo/exo up to >201), and high enantioselectivities (up to 955 e.r.).
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Angew Chem Int Ed Engl
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2015
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Article