Seasonal exacerbation of esophageal eosinophilia in children with eosinophilic esophagitis and allergic rhinitis.
Ann Allergy Asthma Immunol
; 115(3): 224-228.e1, 2015 Sep.
Article
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| MEDLINE
| ID: mdl-26235409
ABSTRACT
BACKGROUND:
Evidence supports a possible link between eosinophilic esophagitis (EoE) and environmental aeroallergens, which can manifest as seasonal exacerbation of esophageal eosinophilia. Few studies have examined this link in pediatric patients with EoE.OBJECTIVE:
To identify the proportion of patients with seasonal induced esophageal eosinophilia.METHODS:
A retrospective chart review was conducted of all patients diagnosed with EoE at the authors' institution. Demographic data were collected by chart review. Seasonal variation or flare was defined as a change from fewer than to at least 15 eosinophils per high-power field and a minimum of a 2-fold increase in eosinophil count between 2 consecutive biopsy specimens in different seasons without dietary or medication modifications.RESULTS:
Of the 1,180 patients with EoE, 160 (14%) were suspected of having aeroallergen-associated triggers by history. Of these 160 patients, 32 (20%) had biopsy examination-confirmed variation of EoE triggered by aeroallergens. Most of these patients were boys (84%), all had a history or examination consistent with allergic rhinitis, and most had a history of asthma (75%). Thirty-two subjects had obvious seasonal variation, 22 of whom also had known food-induced symptoms.CONCLUSION:
Children with EoE and allergic rhinitis might have exacerbations in their esophageal eosinophilia during certain seasons depending on the specific aeroallergens to which they are sensitized. Identification of environmental allergens to sensitized patients is important and can guide therapy.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Progresión de la Enfermedad
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Exposición por Inhalación
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Eosinofilia
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Esofagitis Eosinofílica
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Rinitis Alérgica
Tipo de estudio:
Observational_studies
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Prognostic_studies
Límite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Ann Allergy Asthma Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2015
Tipo del documento:
Article