Your browser doesn't support javascript.
loading
Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands.
Chilmonczyk, Zdzislaw; Bojarski, Andrzej Jacek; Pilc, Andrzej; Sylte, Ingebrigt.
Afiliación
  • Chilmonczyk Z; National Medicines Institute, Chelmska 30/34, 00-725 Warszawa, Poland. z.chilmonczyk@nil.gov.pl.
  • Bojarski AJ; Institute of Nursing and Health Sciences, University of Rzeszów, W. Kopisto 2A, 35-310 Rzeszów, Poland. z.chilmonczyk@nil.gov.pl.
  • Pilc A; Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland. bojarski@if-pan.krakow.pl.
  • Sylte I; Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland. nfpilc@cyf-kr.edu.pl.
Int J Mol Sci ; 16(8): 18474-506, 2015 Aug 07.
Article en En | MEDLINE | ID: mdl-26262615
Serotonin (5-HT) is a monoamine neurotransmitter that plays an important role in physiological functions. 5-HT has been implicated in sleep, feeding, sexual behavior, temperature regulation, pain, and cognition as well as in pathological states including disorders connected to mood, anxiety, psychosis and pain. 5-HT1A receptors have for a long time been considered as an interesting target for the action of antidepressant drugs. It was postulated that postsynaptic 5-HT1A agonists could form a new class of antidepressant drugs, and mixed 5-HT1A receptor ligands/serotonin transporter (SERT) inhibitors seem to possess an interesting pharmacological profile. It should, however, be noted that 5-HT1A receptors can activate several different biochemical pathways and signal through both G protein-dependent and G protein-independent pathways. The variables that affect the multiplicity of 5-HT1A receptor signaling pathways would thus result from the summation of effects specific to the host cell milieu. Moreover, receptor trafficking appears different at pre- and postsynaptic sites. It should also be noted that the 5-HT1A receptor cooperates with other signal transduction systems (like the 5-HT1B or 5-HT2A/2B/2C receptors, the GABAergic and the glutaminergic systems), which also contribute to its antidepressant and/or anxiolytic activity. Thus identifying brain specific molecular targets for 5-HT1A receptor ligands may result in a better targeting, raising a hope for more effective medicines for various pathologies.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptor de Serotonina 5-HT1A / Agonistas del Receptor de Serotonina 5-HT1 / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2015 Tipo del documento: Article País de afiliación: Polonia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptor de Serotonina 5-HT1A / Agonistas del Receptor de Serotonina 5-HT1 / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2015 Tipo del documento: Article País de afiliación: Polonia