DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers.

Abdel-Fatah, Tarek M A; Arora, Arvind; Moseley, Paul M; Perry, Christina; Rakha, Emad A; Green, Andrew R; Chan, Stephen Y T; Ellis, Ian O; Madhusudan, Srinivasan

Abdel-Fatah, Tarek M A; Arora, Arvind; Moseley, Paul M; Perry, Christina; Rakha, Emad A; Green, Andrew R; Chan, Stephen Y T; Ellis, Ian O; Madhusudan, Srinivasan.

Afiliación

Abdel-Fatah TM; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
Arora A; Academic Unit of Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham NG51 PB, UK.
Moseley PM; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
Perry C; Academic Unit of Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham NG51 PB, UK.
Rakha EA; Department of Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK.
Green AR; Department of Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK.
Chan SY; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.
Ellis IO; Department of Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK.
Madhusudan S; Department of Oncology, Nottingham University Hospitals, Nottingham NG5 1PB, UK.

Oncotarget ; 6(26): 21964-78, 2015 Sep 08.

Article en En | MEDLINE | ID: mdl-26267318

Asunto(s)

Reparación del ADN; Neoplasias de la Mama Triple Negativas/genética; Adulto; Anciano; Antraciclinas/uso terapéutico; Proteína BRCA1/genética; Proteína BRCA1/metabolismo; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Femenino; Endonucleasas de ADN Solapado/genética; Endonucleasas de ADN Solapado/metabolismo; Humanos; Persona de Mediana Edad; Pronóstico; Receptores de Estrógenos/metabolismo; Estudios Retrospectivos; Análisis de Supervivencia; Resultado del Tratamiento; Neoplasias de la Mama Triple Negativas/tratamiento farmacológico; Neoplasias de la Mama Triple Negativas/metabolismo; Neoplasias de la Mama Triple Negativas/patología; Proteína 1 de Reparación por Escisión del Grupo de Complementación Cruzada de las Lesiones por Rayos X

Palabras clave

DNA repair; ER-; TNBC; base excision repair; prognosis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Reparación del ADN / Neoplasias de la Mama Triple Negativas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido

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