Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.

Khiati, Salim; Baechler, Simone A; Factor, Valentina M; Zhang, Hongliang; Huang, Shar-yin N; Dalla Rosa, Ilaria; Sourbier, Carole; Neckers, Leonard; Thorgeirsson, Snorri S; Pommier, Yves

Khiati, Salim; Baechler, Simone A; Factor, Valentina M; Zhang, Hongliang; Huang, Shar-yin N; Dalla Rosa, Ilaria; Sourbier, Carole; Neckers, Leonard; Thorgeirsson, Snorri S; Pommier, Yves.

Afiliación

Khiati S; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
Baechler SA; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
Factor VM; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
Zhang H; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
Huang SY; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
Dalla Rosa I; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
Sourbier C; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Neckers L; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Thorgeirsson SS; Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;
Pommier Y; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; pommier@nih.gov.

Proc Natl Acad Sci U S A ; 112(36): 11282-7, 2015 Sep 08.

Article en En | MEDLINE | ID: mdl-26305952

Asunto(s)

ADN-Topoisomerasas de Tipo I/metabolismo; Hepatocitos/metabolismo; Regeneración Hepática/fisiología; Mitocondrias Hepáticas/enzimología; Adenosina Trifosfato/metabolismo; Animales; Western Blotting; Tetracloruro de Carbono/toxicidad; Proliferación Celular/efectos de los fármacos; Proliferación Celular/genética; Células Cultivadas; Enfermedad Hepática Inducida por Sustancias y Drogas/genética; Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo; Enfermedad Hepática Inducida por Sustancias y Drogas/fisiopatología; ADN-Topoisomerasas de Tipo I/genética; ADN Mitocondrial/genética; ADN Mitocondrial/metabolismo; Embrión de Mamíferos/citología; Fibroblastos/metabolismo; Técnicas de Inactivación de Genes; Glutatión/metabolismo; Células HCT116; Hepatocitos/efectos de los fármacos; Hepatocitos/ultraestructura; Humanos; Regeneración Hepática/genética; Ratones Noqueados; Microscopía Electrónica de Transmisión; Mitocondrias Hepáticas/genética; Mitocondrias Hepáticas/metabolismo; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

cell proliferation; liver regeneration; mitochondrial DNA replication; mitochondrial homeostasis; mitochondrial topoisomerase I

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Mitocondrias Hepáticas / ADN-Topoisomerasas de Tipo I / Hepatocitos / Regeneración Hepática Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article

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