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Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy.
Lee, Joong-Jae; Choi, Hyo-Jung; Yun, Misun; Kang, YingJin; Jung, Ji-Eun; Ryu, Yiseul; Kim, Tae Yoon; Cha, Young-Je; Cho, Hyun-Soo; Min, Jung-Joon; Chung, Chul-Woong; Kim, Hak-Sung.
Afiliación
  • Lee JJ; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon (Korea).
  • Choi HJ; New Drug Research Center, LegoChem Biosciences, Inc., Daejeon (Korea).
  • Yun M; Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju (Korea).
  • Kang Y; Department of Systems Biology, Yonsei University, Seoul (Korea).
  • Jung JE; New Drug Research Center, LegoChem Biosciences, Inc., Daejeon (Korea).
  • Ryu Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon (Korea).
  • Kim TY; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon (Korea).
  • Cha YJ; Department of Systems Biology, Yonsei University, Seoul (Korea).
  • Cho HS; Department of Systems Biology, Yonsei University, Seoul (Korea). hscho8@yonsei.ac.kr.
  • Min JJ; Department of Nuclear Medicine, Chonnam National University Medical School, Gwangju (Korea). jjmin@chonnam.ac.kr.
  • Chung CW; New Drug Research Center, LegoChem Biosciences, Inc., Daejeon (Korea). cwchung@legochembio.com.
  • Kim HS; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon (Korea). hskim76@kaist.ac.kr.
Angew Chem Int Ed Engl ; 54(41): 12020-4, 2015 Oct 05.
Article en En | MEDLINE | ID: mdl-26315561

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oligopéptidos / Oximas / Proteínas / Receptores ErbB / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2015 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oligopéptidos / Oximas / Proteínas / Receptores ErbB / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2015 Tipo del documento: Article