A hypoxic ticket to the bone metastatic niche.
Breast Cancer Res
; 17: 122, 2015 Sep 04.
Article
en En
| MEDLINE
| ID: mdl-26337273
ABSTRACT
Hypoxia is a well-characterized driver of aggressive cancer phenotypes, including metastasis. Accumulating evidence suggests that, in addition to having local effects, the consequences of tumour hypoxia can be systemic, leading to the formation of pre-metastatic niches that can later foster metastatic colonization in distant organs. Recent findings have demonstrated that such niches can also form in the bone, possibly revealing new avenues for therapeutic intervention.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Huesos
/
Neoplasias Óseas
/
Hipoxia de la Célula
/
Metástasis de la Neoplasia
Límite:
Female
/
Humans
Idioma:
En
Revista:
Breast Cancer Res
Asunto de la revista:
NEOPLASIAS
Año:
2015
Tipo del documento:
Article
País de afiliación:
Reino Unido