Association of periodontitis with persistent, pro-atherogenic antibody responses.
J Clin Periodontol
; 42(11): 1006-14, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26362847
ABSTRACT
AIM:
To study antibody responses associated with molecular mimicry in periodontitis. MATERIAL &METHODS:
Fifty-four periodontitis cases (mean age 54.0 years) and 44 controls (53.6 years) were examined, after which cases received periodontal treatment. Established immunoassays were used to analyse levels of antibodies against two pathogens, Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg), heat shock proteins (Hsp), Hsp60, Hsp65, and Hsp70, and epitopes of oxidized low-density lipoprotein (oxLDL) (CuOx-LDL and MDA-LDL) in plasma samples that were collected at baseline and after 3 (n = 48) and 6 (n = 30) months.RESULTS:
When age, sex, smoking habit, and the number of teeth were considered in multivariate logistic regressions, Aa and Pg IgG, Hsp65-IgA, CuOx-LDL-IgG and -IgM, and MDA-LDL-IgG antibody levels were associated with periodontitis, whereas Hsp60-IgG2 antibody levels were inversely associated. The Aa antibody levels significantly correlated with the levels of IgA antibodies to Hsp65 and Hsp70, and both OxLDL IgA antibody levels. The levels of antibodies to Pg correlated with IgG antibodies to Hsp60, Hsp70, and both oxLDL antibody epitopes. None of the antibody levels changed significantly after treatment.CONCLUSIONS:
Periodontitis is associated with persistently high levels of circulating antibodies that are reactive with pathogen- and host-derived antigens.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Periodontitis
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
/
Middle aged
Idioma:
En
Revista:
J Clin Periodontol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Suecia