The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes.

Shi, Xianbao; Yang, Shuman; Zhang, Gang; Song, Yonggui; Su, Dan; Liu, Yali; Guo, Feng; Shan, Lina; Cai, Jiqun

Shi, Xianbao; Yang, Shuman; Zhang, Gang; Song, Yonggui; Su, Dan; Liu, Yali; Guo, Feng; Shan, Lina; Cai, Jiqun.

Afiliación

Shi X; a Department of Pharmaceutical Toxicology , School of Pharmacy, China Medical University , Shenyang , China .
Yang S; b Department of Pharmacy , The First Affiliated Hospital of Liaoning Medical University , Jinzhou , China .
Zhang G; c Department of Internal Medicine/Community Health Sciences , University of Manitoba , Winnipeg , Manitoba , Canada .
Song Y; d Department of Medicinal Chemistry , Virginia Commonwealth University , Richmond , VA , USA , and.
Su D; e National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Liu Y; e National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Guo F; e National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Shan L; a Department of Pharmaceutical Toxicology , School of Pharmacy, China Medical University , Shenyang , China .
Cai J; a Department of Pharmaceutical Toxicology , School of Pharmacy, China Medical University , Shenyang , China .

Xenobiotica ; 46(5): 467-76, 2016.

Article en En | MEDLINE | ID: mdl-26372370

Asunto(s)

Inhibidores Enzimáticos del Citocromo P-450/química; Flavonoides/metabolismo; Glucuronosiltransferasa/metabolismo; Animales; Peso Corporal; Perros; Interacciones Farmacológicas; Flavonoides/farmacocinética; Haplorrinos; Humanos; Concentración 50 Inhibidora; Isoenzimas/metabolismo; Cinética; Microsomas Hepáticos/efectos de los fármacos; Microsomas Hepáticos/metabolismo; Preparaciones de Plantas/química; Ratas; Especificidad de la Especie; Porcinos; Porcinos Enanos

Palabras clave

Cytochrome P450 (CYP450); drugdrug interactions; glucuronosyltransferase (UGT); morusin

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Flavonoides / Glucuronosiltransferasa / Inhibidores Enzimáticos del Citocromo P-450 Límite: Animals / Humans Idioma: En Revista: Xenobiotica Año: 2016 Tipo del documento: Article País de afiliación: China

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