Catalytic Asymmetric Construction of α-Quaternary Cyclopentanones and Its Application to the Syntheses of (-)-1,14-Herbertenediol and (-)-Aphanorphine.
Chemistry
; 21(44): 15502-5, 2015 Oct 26.
Article
en En
| MEDLINE
| ID: mdl-26387785
ABSTRACT
A novel and efficient strategy to build α-benzylic quaternary cyclopentanones with excellent enantioselectivities (up to 96 %â
ee) and high yields (up to 99 % yield) has been developed, and its application demonstrated by the first catalytic asymmetric total synthesis of (-)-1,14-herbertenediol and the formal synthesis of (-)-aphanorphine.
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MEDLINE
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En
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Chemistry
Asunto de la revista:
QUIMICA
Año:
2015
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Article