Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins.

Cordomí, Arnau; Navarro, Gemma; Aymerich, María S; Franco, Rafael

Cordomí, Arnau; Navarro, Gemma; Aymerich, María S; Franco, Rafael.

Afiliación

Cordomí A; Laboratory of Computational Medicine, Biostatistics Unit, Universitat Autónoma de Barcelona, 08193 Barcelona, Spain.
Navarro G; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red: Enfermedades neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5 28031, Madrid, Spain. Electronic address: dimart
Aymerich MS; Cell and Molecular Neuropharmacology Laboratory, Neurosciences Division, CIMA (Centro de Investigación Médica Aplicada), Universidad de Navarra, 31008 Pamplona, Spain; Department of Biochemistry and Genetics, School of Science, University of Navarra, Pamplona 31008, Spain.
Franco R; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red: Enfermedades neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5 28031, Madrid, Spain.

Trends Biochem Sci ; 40(10): 548-551, 2015 Oct.

Article en En | MEDLINE | ID: mdl-26410595

RESUMEN

G-Protein-coupled receptors (GPCRs) were classically described as monomers. We now appreciate that they also function as homo- and hetero-oligomers, for which structural information is lacking. Here, we use available 3D structures and biochemical considerations to present and evaluate experimentally testable structural models for GPCR oligomers and associated G proteins.

Asunto(s)

Proteínas de Unión al GTP/química; Proteínas de Unión al GTP/metabolismo; Receptores Acoplados a Proteínas G/química; Receptores Acoplados a Proteínas G/metabolismo; Animales; Humanos; Unión Proteica; Conformación Proteica

Palabras clave

GPCR; dimers; heteromer; model; oligomer; structure

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas de Unión al GTP / Receptores Acoplados a Proteínas G Límite: Animals / Humans Idioma: En Revista: Trends Biochem Sci Año: 2015 Tipo del documento: Article País de afiliación: España

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