Conformational Memory of a Protein Revealed by Single-Molecule Spectroscopy.
J Phys Chem B
; 119(44): 13964-70, 2015 Nov 05.
Article
en En
| MEDLINE
| ID: mdl-26420643
ABSTRACT
Proteins are supramolecular machines that carry out a wide range of different functions, many of which require flexibility. Up until now spontaneous conformational fluctuations of proteins have always been assumed to reflect a stochastic random process. However, if changing between different conformational states was random, then it would be difficult to understand how conformational control of protein function could have evolved. Here we demonstrate that a single protein can show conformational memory. This is exactly the process that can facilitate the evolution of control of switching between two conformational states that can then be used to regulate protein function.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Complejos de Proteína Captadores de Luz
Idioma:
En
Revista:
J Phys Chem B
Asunto de la revista:
QUIMICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania