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Glia-derived neurons are required for sex-specific learning in C. elegans.
Sammut, Michele; Cook, Steven J; Nguyen, Ken C Q; Felton, Terry; Hall, David H; Emmons, Scott W; Poole, Richard J; Barrios, Arantza.
Afiliación
  • Sammut M; Department of Cell and Developmental Biology, University College London, London, WC1E 6BT.
  • Cook SJ; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Nguyen KCQ; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Felton T; Department of Cell and Developmental Biology, University College London, London, WC1E 6BT.
  • Hall DH; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Emmons SW; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Poole RJ; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.
  • Barrios A; Department of Cell and Developmental Biology, University College London, London, WC1E 6BT.
Nature ; 526(7573): 385-390, 2015 Oct 15.
Article en En | MEDLINE | ID: mdl-26469050
Sex differences in behaviour extend to cognitive-like processes such as learning, but the underlying dimorphisms in neural circuit development and organization that generate these behavioural differences are largely unknown. Here we define at the single-cell level-from development, through neural circuit connectivity, to function-the neural basis of a sex-specific learning in the nematode Caenorhabditis elegans. We show that sexual conditioning, a form of associative learning, requires a pair of male-specific interneurons whose progenitors are fully differentiated glia. These neurons are generated during sexual maturation and incorporated into pre-exisiting sex-shared circuits to couple chemotactic responses to reproductive priorities. Our findings reveal a general role for glia as neural progenitors across metazoan taxa and demonstrate that the addition of sex-specific neuron types to brain circuits during sexual maturation is an important mechanism for the generation of sexually dimorphic plasticity in learning.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neuroglía / Caracteres Sexuales / Caenorhabditis elegans / Interneuronas / Aprendizaje Límite: Animals Idioma: En Revista: Nature Año: 2015 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neuroglía / Caracteres Sexuales / Caenorhabditis elegans / Interneuronas / Aprendizaje Límite: Animals Idioma: En Revista: Nature Año: 2015 Tipo del documento: Article