Self-assembling tryptophan-based designer peptides as intracellular delivery vehicles.

Bhardwaj, Ishanki; Jha, Divya; Admane, Prasad; Panda, Amulya K; Haridas, V

Bhardwaj, Ishanki; Jha, Divya; Admane, Prasad; Panda, Amulya K; Haridas, V.

Afiliación

Bhardwaj I; Department of Chemistry, Indian Institute of Technology Delhi (IITD), Hauz Khas, New Delhi 110016, India.
Jha D; Product Development Cell, National Institute of Immunology (NII), Aruna Asaf Ali Marg, New Delhi 110067, India.
Admane P; Product Development Cell, National Institute of Immunology (NII), Aruna Asaf Ali Marg, New Delhi 110067, India.
Panda AK; Product Development Cell, National Institute of Immunology (NII), Aruna Asaf Ali Marg, New Delhi 110067, India.
Haridas V; Department of Chemistry, Indian Institute of Technology Delhi (IITD), Hauz Khas, New Delhi 110016, India. Electronic address: haridasv@iitd.ac.in.

Bioorg Med Chem Lett ; 26(2): 672-676, 2016 Jan 15.

Article en En | MEDLINE | ID: mdl-26631316

ABSTRACT

ABSTRACT

A series of tryptophan-based peptides W1a, b-W4a, b, with diverse architectures were designed and synthesized. These tryptophan containing peptides can self-assemble to spherical particle. This self-assembled system was demonstrated to encapsulate rhodamine B and penetrate the cell membrane.

Asunto(s)

Dendrímeros/química; Portadores de Fármacos/química; Péptidos/química; Rodaminas/administración & dosificación; Triptófano/química; Animales; Línea Celular; Ratones

Palabras clave

Encapsulation; Peptide; Self-assembly; Spherical assembly; Tryptophan

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos / Rodaminas / Triptófano / Portadores de Fármacos / Dendrímeros Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: India

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