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Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFNγ Autoantibodies.
Xie, Yingda L; Rosen, Lindsey B; Sereti, Irini; Barber, Daniel L; Chen, Ray Y; Hsu, Denise C; Qasba, S Sonia; Zerbe, Christa S; Holland, Steven M; Browne, Sarah K.
Afiliación
  • Xie YL; Laboratory of Clinical Infectious Diseases.
  • Rosen LB; Laboratory of Clinical Infectious Diseases.
  • Sereti I; Laboratory of Immunoregulation.
  • Barber DL; Laboratory of Parasitic Diseases at the National Institute of Allergy and Infectious Diseases, National Institutes of Heath, Bethesda.
  • Chen RY; Laboratory of Clinical Infectious Diseases.
  • Hsu DC; Laboratory of Immunoregulation.
  • Qasba SS; Montgomery County Health Department, Silver Spring, Maryland.
  • Zerbe CS; Laboratory of Clinical Infectious Diseases.
  • Holland SM; Laboratory of Clinical Infectious Diseases.
  • Browne SK; Laboratory of Clinical Infectious Diseases.
Clin Infect Dis ; 62(6): 770-773, 2016 Mar 15.
Article en En | MEDLINE | ID: mdl-26646678
ABSTRACT
Interferon-gamma (IFNγ) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNγ-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFNγ contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Autoanticuerpos / Tuberculosis Miliar / Interferón gamma / Anticuerpos Neutralizantes / Antibacterianos Límite: Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Autoanticuerpos / Tuberculosis Miliar / Interferón gamma / Anticuerpos Neutralizantes / Antibacterianos Límite: Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2016 Tipo del documento: Article