Your browser doesn't support javascript.
loading
T Cell Fate at the Single-Cell Level.
Buchholz, Veit R; Schumacher, Ton N M; Busch, Dirk H.
Afiliación
  • Buchholz VR; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), 81675 München, Germany; email: veit.buchholz@tum.de , dirk.busch@tum.de.
  • Schumacher TN; Division of Immunology, The Netherlands Cancer Institute (NKI), 1066 CX Amsterdam, The Netherlands; email: t.schumacher@nki.nl.
  • Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), 81675 München, Germany; email: veit.buchholz@tum.de , dirk.busch@tum.de.
Annu Rev Immunol ; 34: 65-92, 2016 05 20.
Article en En | MEDLINE | ID: mdl-26666651
T cell responses display two key characteristics. First, a small population of epitope-specific naive T cells expands by several orders of magnitude. Second, the T cells within this proliferating population take on diverse functional and phenotypic properties that determine their ability to exert effector functions and contribute to T cell memory. Recent technological advances in lineage tracing allow us for the first time to study these processes in vivo at single-cell resolution. Here, we summarize resulting data demonstrating that although epitope-specific T cell responses are reproducibly similar at the population level, expansion potential and diversification patterns of the offspring derived from individual T cells are highly variable during both primary and recall immune responses. In spite of this stochastic response variation, individual memory T cells can serve as adult stem cells that provide robust regeneration of an epitope-specific tissue through population averaging. We discuss the relevance of these findings for T cell memory formation and clinical immunotherapy.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfocitos T / Diferenciación Celular / Células Madre Adultas / Análisis de la Célula Individual / Inmunoterapia Límite: Animals / Humans Idioma: En Revista: Annu Rev Immunol Año: 2016 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfocitos T / Diferenciación Celular / Células Madre Adultas / Análisis de la Célula Individual / Inmunoterapia Límite: Animals / Humans Idioma: En Revista: Annu Rev Immunol Año: 2016 Tipo del documento: Article