Reprogramming of liver cells into insulin-producing cells.
Best Pract Res Clin Endocrinol Metab
; 29(6): 873-82, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26696516
ABSTRACT
Tissue replacement is a promising direction for the treatment of diabetes, which will become widely available only when islets or insulin-producing cells that will not be rejected by the diabetic recipients are available in unlimited amounts. The present review addresses the research in the field of generating functional insulin-producing cells by transdifferentiation of adult liver cells both in vitro and in vivo. It presents recent knowledge of the mechanisms which underlie the process and assesses the challenges which should be addressed for its efficient implementation as a cell based replacement therapy for diabetics.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Hepatocitos
/
Células Secretoras de Insulina
/
Transdiferenciación Celular
/
Regeneración Hepática
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Best Pract Res Clin Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2015
Tipo del documento:
Article