SOS response and its regulation on the fluoroquinolone resistance.
Ann Transl Med
; 3(22): 358, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26807413
ABSTRACT
Bacteria can survive fluoroquinolone antibiotics (FQs) treatment by becoming resistant through a genetic change-mutation or gene acquisition. The SOS response is widespread among bacteria and exhibits considerable variation in its composition and regulation, which is repressed by LexA protein and derepressed by RecA protein. Here, we take a comprehensive review of the SOS gene network and its regulation on the fluoroquinolone resistance. As a unique survival mechanism, SOS may be an important factor influencing the outcome of antibiotic therapy in vivo.
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Bases de datos:
MEDLINE
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En
Revista:
Ann Transl Med
Año:
2015
Tipo del documento:
Article
País de afiliación:
China