3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.
Virology
; 490: 49-58, 2016 03.
Article
en En
| MEDLINE
| ID: mdl-26828465
ABSTRACT
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was identified in 2012 as the causative agent of a severe, lethal respiratory disease occurring across several countries in the Middle East. To date there have been over 1600 laboratory confirmed cases of MERS-CoV in 26 countries with a case fatality rate of 36%. Given the endemic region, it is possible that MERS-CoV could spread during the annual Hajj pilgrimage, necessitating countermeasure development. In this report, we describe the clinical and radiographic changes of rhesus monkeys following infection with 5×10(6) PFU MERS-CoV Jordan-n3/2012. Two groups of NHPs were treated with either a human anti-MERS monoclonal antibody 3B11-N or E410-N, an anti-HIV antibody. MERS-CoV Jordan-n3/2012 infection resulted in quantifiable changes by computed tomography, but limited other clinical signs of disease. 3B11-N treated subjects developed significantly reduced lung pathology when compared to infected, untreated subjects, indicating that this antibody may be a suitable MERS-CoV treatment.
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1
Bases de datos:
MEDLINE
Asunto principal:
Infecciones por Coronavirus
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Coronavirus del Síndrome Respiratorio de Oriente Medio
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Pulmón
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Anticuerpos Monoclonales
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Anticuerpos Antivirales
Límite:
Animals
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Humans
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Male
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En
Revista:
Virology
Año:
2016
Tipo del documento:
Article