Your browser doesn't support javascript.
loading
Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces.
Nakahashi-Oda, Chigusa; Udayanga, Kankanam Gamage Sanath; Nakamura, Yoshiyuki; Nakazawa, Yuta; Totsuka, Naoya; Miki, Haruka; Iino, Shuichi; Tahara-Hanaoka, Satoko; Honda, Shin-ichiro; Shibuya, Kazuko; Shibuya, Akira.
Afiliación
  • Nakahashi-Oda C; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Udayanga KG; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Nakamura Y; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Nakazawa Y; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Totsuka N; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Miki H; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Iino S; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Tahara-Hanaoka S; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Honda S; Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan.
  • Shibuya K; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Shibuya A; Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Nat Immunol ; 17(4): 441-50, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26855029
Epithelial tissues continually undergo apoptosis. Commensal organisms that inhabit the epithelium influence tissue homeostasis, in which regulatory T cells (Treg cells) have a central role. However, the physiological importance of epithelial cell apoptosis and how the number of Treg cells is regulated are both incompletely understood. Here we found that apoptotic epithelial cells negatively regulated the commensal-stimulated proliferation of Treg cells. Gut commensals stimulated CX3CR1(+)CD103(-)CD11b(+) dendritic cells (DCs) to produce interferon-ß (IFN-ß), which augmented the proliferation of Treg cells in the intestine. Conversely, phosphatidylserine exposed on apoptotic epithelial cells suppressed IFN-ß production by the DCs via inhibitory signaling mediated by the cell-surface glycoprotein CD300a and thus suppressed Treg cell proliferation. Our findings reveal a regulatory role for apoptotic epithelial cells in maintaining the number of Treg cell and tissue homeostasis.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Interferón beta / Apoptosis / Linfocitos T Reguladores / Mucosa Respiratoria / Epidermis / Células Epiteliales / Microbioma Gastrointestinal / Mucosa Intestinal Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Interferón beta / Apoptosis / Linfocitos T Reguladores / Mucosa Respiratoria / Epidermis / Células Epiteliales / Microbioma Gastrointestinal / Mucosa Intestinal Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Japón