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Concise Review: Plasma and Nuclear Membranes Convey Mechanical Information to Regulate Mesenchymal Stem Cell Lineage.
Uzer, Gunes; Fuchs, Robyn K; Rubin, Janet; Thompson, William R.
Afiliación
  • Uzer G; Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Fuchs RK; School of Health and Rehabilitation Sciences, Department of Physical Therapy, Indiana University, Indianapolis, Indiana, USA.
  • Rubin J; Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Thompson WR; School of Health and Rehabilitation Sciences, Department of Physical Therapy, Indiana University, Indianapolis, Indiana, USA.
Stem Cells ; 34(6): 1455-63, 2016 06.
Article en En | MEDLINE | ID: mdl-26891206
ABSTRACT
Numerous factors including chemical, hormonal, spatial, and physical cues determine stem cell fate. While the regulation of stem cell differentiation by soluble factors is well-characterized, the role of mechanical force in the determination of lineage fate is just beginning to be understood. Investigation of the role of force on cell function has largely focused on "outside-in" signaling, initiated at the plasma membrane. When interfaced with the extracellular matrix, the cell uses integral membrane proteins, such as those found in focal adhesion complexes to translate force into biochemical signals. Akin to these outside-in connections, the internal cytoskeleton is physically linked to the nucleus, via proteins that span the nuclear membrane. Although structurally and biochemically distinct, these two forms of mechanical coupling influence stem cell lineage fate and, when disrupted, often lead to disease. Here we provide an overview of how mechanical coupling occurs at the plasma and nuclear membranes. We also discuss the role of force on stem cell differentiation, with focus on the biochemical signals generated at the cell membrane and the nucleus, and how those signals influence various diseases. While the interaction of stem cells with their physical environment and how they respond to force is complex, an understanding of the mechanical regulation of these cells is critical in the design of novel therapeutics to combat diseases associated with aging, cancer, and osteoporosis. Stem Cells 2016;341455-1463.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Membrana Celular / Linaje de la Célula / Células Madre Mesenquimatosas / Membrana Nuclear Límite: Animals / Humans Idioma: En Revista: Stem Cells Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Membrana Celular / Linaje de la Célula / Células Madre Mesenquimatosas / Membrana Nuclear Límite: Animals / Humans Idioma: En Revista: Stem Cells Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos