MicroRNAs as novel therapeutic targets to treat kidney injury and fibrosis.

Gomez, Ivan G; Nakagawa, Naoki; Duffield, Jeremy S

Gomez, Ivan G; Nakagawa, Naoki; Duffield, Jeremy S.

Afiliación

Gomez IG; Research and Development, Biogen, Cambridge, Massachusetts; Division of Nephrology, Departments of Medicine and Pathology, University of Washington, Seattle, Washington; and.
Nakagawa N; Division of Nephrology, Departments of Medicine and Pathology, University of Washington, Seattle, Washington; and Division of Nephrology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Duffield JS; Research and Development, Biogen, Cambridge, Massachusetts; Division of Nephrology, Departments of Medicine and Pathology, University of Washington, Seattle, Washington; and jeremy.duffield@biogen.com.

Am J Physiol Renal Physiol ; 310(10): F931-44, 2016 05 01.

Article en En | MEDLINE | ID: mdl-26911854

Asunto(s)

MicroARNs/metabolismo; Terapia Molecular Dirigida; Oligonucleótidos/uso terapéutico; Biogénesis de Organelos; Insuficiencia Renal/metabolismo; Animales; Ácidos Grasos/metabolismo; Fibrosis; Humanos; Riñón/patología; MicroARNs/antagonistas & inhibidores; Oligonucleótidos/farmacología; Oxidación-Reducción; Insuficiencia Renal/tratamiento farmacológico; Insuficiencia Renal/etiología

Palabras clave

Dicer; angiogenesis; chronic kidney disease; fatty acid oxidation; macrophage activation; microRNAs; mitochondria

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oligonucleótidos / Biogénesis de Organelos / MicroARNs / Insuficiencia Renal / Terapia Molecular Dirigida Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Am J Physiol Renal Physiol Asunto de la revista: FISIOLOGIA / NEFROLOGIA Año: 2016 Tipo del documento: Article

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